Research released today highlights advances in the use of CRISPR-Cas9 and human induced pluripotent stem cell technologies to identify novel therapeutic targets for neurological disorders such as schizophrenia and addiction. The studies were presented at Neuroscience 2017, the annual meeting of the Society for Neuroscience and the world’s largest source of emerging news about brain science and health.
CRISPR-Cas9 is a versatile and highly accurate gene-editing technology that allows researchers to modify specific parts of an organism’s genome by altering sections of the DNA sequence. Human induced pluripotent stem cells (iPSCs) are a genetic research tool that can be generated from adult human cells, bypassing the need for using tissue from embryos (along with the associated controversy). The stem cells can be converted into any type of cell in the body, enabling research in multiple human systems. New applications of these relatively recent technologies are facilitating research at the gene-specific level, creating potential for the development of new therapies.
Today’s new findings show that:
Other recent findings discussed show that:
“Today’s findings exemplify the many advances we’ve made in using CRISPR-Cas9 and human induced pluripotent stem cell technologies and the amazing discoveries that have resulted,” said Hideyuki Okano, MD, PhD, of the Keio University School of Medicine in Tokyo, Japan. “Neuroscientists are using these new gene-editing and molecular tools to develop potential therapeutic targets across multiple disease fronts.”