If children develop severe respiratory illness before two years old, they are at least double the risk of developing asthma later in childhood, a study of NSW babies has found.
A study of all children born in NSW between 2000 and 2010 has found that if they develop severe respiratory illness before two years old, they are at least double the risk of developing asthma later in childhood.
The research published in BMJ Open is the first study to demonstrate the increased risk of asthma hospitalisation following severe Respiratory Syncytial Viral disease (RSV) in different groups of high-risk Australian children.
RSV is a major cause of respiratory illness in young children. Almost all Australian children will have RSV before they turn three, but it can be serious and require hospitalisation.
The 847,516 children were divided into three groups: non-Indigenous children born preterm or with a low birth weight, Indigenous children, and all other non-Indigenous children.
The study’s first author, UNSW lecturer Dr Nusrat Homaira, says in all three groups the risk was comparable.
Children hospitalised for RSV before their second birthday had double the risk of developing asthma at the age of three compared to children who were not hospitalised for RSV, and that risk continued until children were seven years of age.
“The incidence of severe RSV disease is exceptionally high among children who were born preterm and among Indigenous children in NSW,” Dr Homaira says.
“In a previous study, we have already shown that the risk of developing severe RSV bronchiolitis, compared to otherwise healthy children, is 10 times more for children who are born preterm and two times more for Indigenous children.
“Parents should be aware that smoking is one of the strongest modifiable risk factors for developing severe RSV bronchiolitis for all children.”
Australia has a high prevalence of paediatric asthma compared to other developed countries, with approximately 21% of children aged 0-15 having a past diagnosis of asthma, and 11% currently diagnosed with the condition.
In 2014, more than 13,000 children aged 1-17 presented to NSW emergency departments with asthma – two thirds of all hospital presentations for this age group. RSV-associated lower respiratory tract infections are also very high in NSW, costing the health system more than $9 million annually.
Dr Homaira says: “There are several vaccines for RSV being tested in clinical trials which will be extremely helpful in not only reducing bronchiolitis, but hopefully the subsequent asthma especially in preterm and Indigenous children.”
Association between respiratory syncytial viral disease and the subsequent risk of the first episode of severe asthma in different subgroups of high-risk Australian children: a whole-of-population-based cohort study BMJ Open 2017;7:e017936. DOI: 10.1136/bmjopen-2017-017936